Synthetic Utility of Pyridinium Bromide: Synthesis and Antimicrobial Activity of Novel 2,4,6‐Trisubstituted Pyridines Having Pyrazole Moiety

Fourteen potentially bioactive pyridines, pendant to pyrazole moiety, were synthesized and evaluated in vitro for their antimicrobial potential. Treatment of 2‐bromo‐1‐(5‐methyl‐1‐phenyl‐1H‐pyrazol‐4‐yl)ethanone with pyridine afforded the corresponding pyridinium bromide salt. Reaction of the latter salt with α,β‐unsaturated ketones yielded the corresponding 2,4,6‐trisubstituted pyridine derivatives. The structures of the synthesized products were confirmed by all possible spectral data. The antimicrobial activity of some selected products was evaluated by using well‐diffusion agar assay and minimum inhibitory concentration determination, and the results revealed good‐to‐moderate activities compared with reference drugs.