Facile Synthesis of Phenanthridinone Alkaloids via Suzuki–Miyaura Cross‐coupling |
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Abstract: | Phenanthridinone alkaloids crinasiadine 1 and N‐alkylcrinasiadines 6 , 7 , 8 , 9 , 10 have been synthesized based on palladium‐catalyzed tandem C–C and C–N bond formation starting from 2‐aminophenylboronic acid and 2‐bromobenzoate in short steps. Related alkaloids, 5,6‐dihydrobicolorine 2 , trisphaeridine 3 , and bicolorine 12 have also been synthesized. |
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