Water‐Based Synthesis of Novel 6, 7‐Dihydrobenzofuran‐4 (5H) ‐Ones

A simple, efficient, and high yielding one‐pot protocol for the synthesis of 4‐keto‐4,5,6,7‐tetrahydrobenzofurans has been developed by three‐component coupling reaction of dimedone, phenylglyoxal monohydrate, and heteroaryl amines in eco‐friendly solvent water under reflux conditions. The protocol avoids the use of catalysts, toxic solvents, tedious work‐up procedures, and chromatographic separation. The reaction proceeds at fast rates within 45 min and provides access to a variety of fused‐ring furans in high to excellent yields.