Functional Ionic Liquids Promoted Double Michael Reaction of Benzofuran‐3‐one or 1‐Indone and Symmetric Dienones: Construction of Spiro[benzofuran‐2,1’‐cyclohexane]‐3‐one or Spiro[cyclohexane‐1,2’‐indene]‐1’,4(3’H)‐dione Derivatives |
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Abstract: | The double Michael reactions between benzofuran‐3‐one or 1‐indone and symmetric dienones in the presence of catalytic ionic liquids were successfully developed and spirobenzofuran‐2,1’‐cyclohexane]‐3‐one or spirocyclohexane‐1,2’‐indene]‐1’,4(3’H )‐dione derivatives containing a spiro quaternary stereogenic center, which widely exist in biologically active products and building blocks in organic synthesis, were obtained in excellent yields (up to 99%). This catalytic system was also extended to the double Michael reaction of less reactive 1‐indone and the desired products were also obtained in 31%‐62% yields. The catalytic system was highly active and efficient for a broad of substrates under mild conditions. |
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Keywords: | double Michael reactions spiro[benzofuran‐2 1’ ‐cyclohexane]‐3‐one spiro[cyclohexane‐1 2’ ‐indene]‐ 1’ 4(3’ H)‐dione functional ionic liquids |
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