| Abstract: | Sensitive disposable sensors have been constructed for potentiometric determination of Biperiden hydrochloride (BPHCl) based on multi‐walled carbon nanotubes–polyvinylchloride (MWNTs–PVC) composite in presence of dibenzo 24‐crown‐8‐ ether as a molecular receptor. Electrode matrix composition was optimized on the basis of the nature of the electroactive material, ionic sites, membrane plasticizer, and nanomaterial. The fabricated sensors showed improved selectivity and sensitivity towards biperiden hydrochloride with Nernstian cationic compliance of 59.8±1.1 mV decade−1 in the concentration range from 10−6 to 10−2 mol L−1. Modification with carbon nanotubes promote electron‐transfer processes and enhanced the stability of potential reading, response time and shelf lifetime of sensors. The proposed method was applied for potentiometric assay of BPHCl in dosage formulation and biological fluids under batch and flow injection analysis (FIA) with average recoveries agreeable with the reported official methods. |
