Regioselective Synthesis of SCF3‐Substituted 2,4‐Diarylquinazoline Using AgSCF3 as Trifluoromethylthiolation Reagent

A facile and efficient route to 4‐aryl‐2‐2‐(trifluoromethylthio) aryl]quinazoline derivatives through a tandem directed Rh‐catalyzed C‐H iodination and trifluoromethylthiolation is described. The reaction proceeded under mild reaction conditions, exhibited good functional group tolerance with a broad scope of substrate and excellent regioselectivity in good to excellent yields.