N,N′‐Dialkyl‐4‐Aryl‐3,4‐Dihydropyrimidinones and Thiones: Ceric Ammonium Nitrate Catalyzed Synthesis and Molecular Structure Determination by X‐ray Crystallography

This work presents a microwave assisted solvent‐free synthesis of N,N ′‐dialkyl‐4‐aryl‐3,4‐dihydropyrimidinones/thiones in the presence of Ceric Ammonium Nitrate (CAN) via direct condensation of aromatic aldehydes, β‐keto ester, and N,N ′‐dialkylurea/thiourea. The highlights of the methodology adopted are (i) facile condensation of the reactants into product without any side‐products, and (ii) short reaction time with high yield and good purity. All the compounds synthesized were characterized and established by spectroscopic techniques such as FTIR, ¹H NMR, ¹³C NMR, and Mass. The structure of the compound is further corroborated by single crystal X‐ray diffraction analysis.