Abstract: | Inorganic antibacterial agents such as metal nanoparticles (NPs) are very important in biomedical and pharmaceutical areas. There are many methods of synthesizing these NPs, but all of them have their own disadvantages. In this study, ultrasonic‐assisted spark discharge is employed to produce colloidal silver (Ag) and zinc oxide (ZnO) NPs which are stable without using any stabilizers or surfactants. Different tests such as X‐ray diffraction, field emission scanning electron microscopy, and ultraviolet–visible absorption spectroscopy are used for the characterization of the quantity and quality of these NPs, and their antibacterial activity is evaluated by the disk diffusion method and determination of the minimum inhibitory concentrations against Escherichia coli . The results show that the overall antibacterial activity of Ag NPs is higher than that of ZnO NPs. |