Synthesis and Antibacterial Screening of 1,3,4‐Thiadiazoles, 1,2,4‐Triazoles,and 1,3,4‐Oxadiazoles Containing Piperazine Nucleus

A series of novel 1,3,4‐thiadiazoles, 1,2,4‐triazoles, and 1,3,4‐oxadiazoles were synthesized by cyclization of substituted 1‐(2‐(2‐chlorophenyl)‐2‐(4‐(2,3‐dichlorophenyl)piperazin‐1‐yl)acetyl)thiosemicarbazide. The structures of all newly synthesized compounds were elucidated on the basis of spectral studies. Some of them were screened for their antibacterial activity. The compounds 6b , 6c , 8e , 9a , and 9b have shown moderate activity towards Bacillus Subtilis and Escherichia Coli .