| Abstract: | An electrochemical sensor for paracetamol (PC) based on the hexacyanoferate(III) intercalated Ni?Al layered double hydroxide (Ni?Al?HCF) was presented. The as‐prepared LDH structurally and morphologically was characterized by scanning electron microscopy, X‐ray diffraction, and Fourier transform IR. Electrochemical studies revealed that Ni?Al?HCF film modified glassy carbon (GC) electrode exhibited remarkable electrocatalytic activity toward the oxidation of paracetamol. The electrochemical behavior of PC on the Ni?Al?HCF film was investigated in detail. Under optimum experimental conditions, the electrocatalytic response of the modified GC electrode was linear in the PC concentration range 3×10?6?–1.5×10?3 mol L?1, with a detection limit of 8×10?7 mol L?1 (S/N=3), using hydrodynamic amperometry. In addition, the modified electrode exhibited good reproducibility, long‐term stability and anti‐interference property. The fabricated sensor was successfully applied to determination of PC in various pharmaceutical preparations such as tablets, oral solution, and oral drops. Finally, the method was validated by the analysis of paracetamol spiked human serum samples, and good recoveries were obtained in the range of 99.2–103 %. |
