Synthesis of 4-aminopyrido[3,2-b]indole derivatives |
| |
Authors: | S. Yu. Ryabova L. M. Alekseeva E. A. Lisitsa V. G. Granik |
| |
Affiliation: | (1) State Scientific Center for Antibiotics, 3a ul. Nagatinskaya, 117003 Moscow, Russian Federation |
| |
Abstract: | 3-Arylamino-2-formylindoles were converted into oximes and then acetylated to give the corresponding O-acetyl derivatives. Chloroacetylation of the latter was accompanied by elimination of acetic acid, yielding 3-(N-aryl-N-chloroacetyl)amino-2-cyanoindoles. When heated in pyridine, these nitriles underwent cyclization into novel δ-carboline derivatives: 4-amino-1-aryl-2-oxo-1,2-dihydropyrido[3,2-b]indol-3-yl)pyridinium chlorides. The structures of the compounds obtained were proved by IR and 1H NMR spectroscopy and mass spectrometry. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1201—1207, July, 2006. |
| |
Keywords: | 3-arylaminoindoles oximes 3-(N-aryl-N-chloroacetyl)amino-2-formylindoles cyanoindoles δ -carbolines |
本文献已被 SpringerLink 等数据库收录! |
|