| 基于分子印迹膜修饰丝网印刷电极的地西泮电化学传感器 |
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| 引用本文： | 刘晓芳,姚冰,刘国艳,柴春彦.基于分子印迹膜修饰丝网印刷电极的地西泮电化学传感器[J].分析测试学报,2010,29(11). |
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| 作者姓名： | 刘晓芳 姚冰 刘国艳 柴春彦 |
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| 作者单位： | 上海交通大学农业与生物学院; |
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| 基金项目： | 国家高技术研发发展计划(863计划) |
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| 摘 要： | 以地西泮为模板分子,采用循环伏安法在一次性丝网印刷电极表面原位电聚合形成聚邻苯二胺膜,洗脱除去模板分子后得到地西泮分子印迹膜修饰丝网印刷电极。利用差示脉冲法对印迹膜和非印迹膜进行评价,表征了电极表面膜的电化学性质。以KI为印迹电极和底液间的探针,建立了一种间接检测地西泮的传感方法。该传感器的敏感元件为修饰有分子印迹膜的丝网印刷电极,其制备和更换非常方便。用于电化学检测时,样品的富集时间为3min,地西泮的浓度在2.0×10-7～1.0×10-5mol/L范围内与峰电流呈良好的线性关系,检出限为2.5×10-8mol/L,基于猪肉样品的加标回收率为92%～95%。将该传感器初步用于实际样品分析,结果满意。
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| 关 键 词： | 分子印迹 电聚合 地西泮 电化学传感器 |
Electrochemical Sensor for Diazepam Based on Molecularly Imprinted Film Modified Screen Printed Electrode |
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| LIU Xiao-fang,YAO Bing,LIU Guo-yan,CHAI Chun-yan.Electrochemical Sensor for Diazepam Based on Molecularly Imprinted Film Modified Screen Printed Electrode[J].Journal of Instrumental Analysis,2010,29(11). |
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| Authors: | LIU Xiao-fang YAO Bing LIU Guo-yan CHAI Chun-yan |
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| Institution: | LIU Xiao-fang,YAO Bing,LIU Guo-yan,CHAI Chun-yan(School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai 200240,China) |
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| Abstract: | A molecularly imprinted film modified screen printed electrode(SPE) was prepared by cyclic voltammetry with electro-polymerization of o-phenylenediamine in the presence of diazepam which was removed later.The electrochemical characteristics of the imprinted and non-imprinted films were evaluated by differential pulse voltammogram.Potassium iodide was used as the probe between the modified electrode and the base solution,and a method for determination of diazepam was established.The molecularly imprinted fil... |
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| Keywords: | molecularly imprinting electro-polymerization diazepam electrochemical sensor |
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