| 磺酰脲的类Mannich反应研究 |
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| 引用本文： | 戴庆 陈茹玉. 磺酰脲的类Mannich反应研究[J]. 高等学校化学学报, 1997, 18(1): 64-67 |
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| 作者姓名： | 戴庆 陈茹玉 |
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| 作者单位： | 南开大学元素有机化学研究所及国家重点实验室, 天津, 300071 |
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| 摘 要： | 研究了对甲苯磺酰脲与取代苯甲醛及亚磷酸二酯的类Mannich反应,用竞争反应的方法对不同胺组分发生类Mannich反应的活性进行了比较.合成了一系列α-对甲苯磺酰脲基磷酸二酯的化合物.产物的结构得到1HNMR和元素分析的证明.初步生物活性测定结果表明其中某些化合物具有很好的抗烟草花叶病毒活性。
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| 关 键 词： | 对甲苯磺酰脲 类Mannich反应 &alpha -氨基膦酸 生物活性 抗烟草花叶病毒 |
| 收稿时间： | 1996-01-05 |
Studies on the Mannich-type Reaction of p-Toluenesulfonylurea |
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| DAI Qing,CHEN Ru-Yu. Studies on the Mannich-type Reaction of p-Toluenesulfonylurea[J]. Chemical Research In Chinese Universities, 1997, 18(1): 64-67 |
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| Authors: | DAI Qing CHEN Ru-Yu |
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| Affiliation: | Institute of Elemento-Organic Chemistry and State's Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin, 300071 |
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| Abstract: | The Mannich-type reaction invoIving p-toluenesulfonylurea with aromatic aldehy-des and dialkyl phosphite was studied and the reactivities of various kinds of amides were compared by a competing reaction. A new type of a-amino phosphonic acid derivatives were synthesized and the structures of the products were confirmed by lH NMR and elemental analyses. The bioassay shows that some of them possess good anti-TMV(Tobacco Mosaic Virus) activity. |
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| Keywords: | p-Toluenesulfonylurea Mannich-type reaction α-Amino phosphonic acid Biological activity Anti-TMV |
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