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| 镉(Ⅱ)-环丙沙星化合物的合成、晶体结构、抗菌与抗肿瘤活性 | |
| 引用本文： | 范振中,傅旭春,王国平,朱龙观. 镉(Ⅱ)-环丙沙星化合物的合成、晶体结构、抗菌与抗肿瘤活性[J]. 无机化学学报, 2005, 21(9): 1363-1366 |
| 作者姓名： | 范振中 傅旭春 王国平 朱龙观 |
| 作者单位： | 1. 大庆石油学院石油工程系,大庆,163318 2. 浙江大学城市学院药学系,杭州,310015 3. 浙江大学化学系,杭州,310027 |
| 基金项目： | 国家自然科学基金项目(No.50073019)，浙江省教育厅科研项目(No.G2040417)资助 |
| 摘 要： | A new Cadmium(Ⅱ)-Ciprofloxacin ionic compound, (HCPFX)2[CdCl4]·3H2O, is synthesized and its crystal structure is determined. The crystallography data are as follows, monoclinic, space group P21/c, a=1.010 39(6) nm, b=1.399 89(9) nm, c=2.822 45(18) nm, β=95.765 0(10)°, V=3.972 0(4) nm3, Z=4, Dc=1.627 g·cm-3, F(000)=1 984. R1=0.054 0, wR2=0.150 3 (I>2σ(I)). In the title compound, four chloride ions are coordinated to the cadmium ion forming a slightly distorted tetrahedron. Both Ciprofloxacin and the compound were assayed against gram-positive and gram-negative bacteria by doubling dilutions method, the compound shows the same minimal inhibitory concentration (MIC) as the Ciprofloxacin against S. Aureus, M. Lutens, E. Coli and P. Aeruginosa bacteria. The inhibitory effect of the two compounds on leukemia HL-60 cell line has been measured by using MTT (Methyl-Thiazol-Tetrozolium) assay method. The results indicate that the complex has very strong inhibitory effect on HL-60 cell line. CCDC: 259367. |
| 关 键 词： | 镉(Ⅱ)化合物； 环丙沙星； 晶体结构； 抗菌与抗肿瘤活性 |
| 文章编号： | 1001-4861（2005）09-1363-04 |
| 收稿时间： | 2005-01-17 |
| 修稿时间： | 2005-06-16 |
Synthesis, Crystal Structure, Antibacterial and Antitumor Activities of a New Cadmium(Ⅱ)-Ciprofloxacin Ionic Compound |
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| FAN Zhen-Zhong,FU Xu-Chun,WANG Guo-Ping and ZHU Long-Guan. Synthesis, Crystal Structure, Antibacterial and Antitumor Activities of a New Cadmium(Ⅱ)-Ciprofloxacin Ionic Compound[J]. Chinese Journal of Inorganic Chemistry, 2005, 21(9): 1363-1366 | |
| Authors: | FAN Zhen-Zhong FU Xu-Chun WANG Guo-Ping ZHU Long-Guan |
| Affiliation: | Petroleum Engineering Department of Daqing Petroleum Institute, Daqing 163318,Department of Pharmacy, City College, Zhejiang University, Hangzhou 310015,Department of Chemistry, Zhejiang University, Hangzhou 310027 and Department of Chemistry, Zhejiang University, Hangzhou 310027 |
| Abstract: | |
| Keywords: | cadmium compound ciprofloxacin crystal structure antibacterial and antitumor activity |
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