| 无机物的ADME/Tox研究 |
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| 引用本文： | 杨晓达,杨晓改.无机物的ADME/Tox研究[J].化学进展,2002,14(4):273-278. |
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| 作者姓名： | 杨晓达 杨晓改 |
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| 作者单位： | 北京大学药学院化学生物学系，北京大学天然及仿生药物国家重点实验室 北京 100083 |
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| 基金项目： | 北京大学 985预防药学项目，天然及仿生药物国家重点实验室支持 |
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| 摘 要： | 无机物的吸收、分配、代谢和排除以及毒性（ADME/Tox)研究在药物和毒物研究中非常重要，近年来发展在细胞层次上应用高通量和计算机等技术系统探索药物先导化合物的ADME/Tox发展迅速。金属和其它无机化合物的ADME/Tox研究在国内外都还是一个新兴的、具有广阔发展前途的跨学科研究领域。本文综述了国内外对于铁和铜以及稀土等金属的化合物的ADME/Tox研究结果，提出了一些应该开展的工作和有待解决的问题。
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| 关 键 词： | 无机物 ADME/Tox 药物动力学 药物化学 金属离子 |
| 文章编号： | 1005-281X(2002)04-0273-06 |
ADME/Tox Approach in Inorganic Medicinal Chemistry |
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| Yang Xiaoda,Yang Xiaogai.ADME/Tox Approach in Inorganic Medicinal Chemistry[J].Progress in Chemistry,2002,14(4):273-278. |
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| Authors: | Yang Xiaoda Yang Xiaogai |
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| Institution: | Department of Chemical Biology, School of Pharmaceutical Sciences; National Research Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China |
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| Abstract: | High throughput techniques and computer models are widely used in the absorption, distribution, metabolism, excretion, and toxicity (ADME/Tox) studies of drugs. Study of metal complexes and other inorganic compounds via the approach of ADME/Tox is a novel, active, and promising research area. The absorption, transport, cellular uptake, and metabolism of iron and copper currently received more attentions and some of the mechanisms were elucidated. The across membrane transportation of lanthanide ions was found to be through multiple pathways. Advances in the ADME/Tox research of other inorganic compounds were also reviewed. |
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| Keywords: | inorganic pharmaceutics ADME/Tox pharmacokinetics pharmaceutical chemistry metal ions |
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