| Synthesis,Bioactivity and Crystal Structure Analysis of 2-（Benzo [d]isothiazol-3-yloxy）-N-（3-cyano-l-（4- fluorophenyl）-lH-pyrazol-5-yl） Acetamide |
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| 作者姓名： | YU Peng, LI Xi, HU Jun, XU Yan-Hua |
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| 作者单位： | [1]College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009, China; [2]College of Environment, Nanjing University of Technology, Nanjing 210009, China; [3]Jiangsu Key Laboratory of Industrial Water-conservation & Emission Reduction, Nanjing 210009, China; [4]Post-doctoral Research Station of Chemical Engineering and Technology, Nanjing University of Technology, Nanjing 210009, China |
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| 基金项目： | The generous financial support of this work from 2011 Key projects of Natural Science of Jiangsu province-owned colleges （No. 11YdA610001）, Innovation project designated for graduate students of Jiangsu province （No. CXZZ13_0452）, and the Postdoctoral research funding plan of Jiangsu province （No. 1202106C） |
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| 摘 要： | A novel benzisothiazolin-3-one derivative, 2-（benzo[d]isothiazol-3-yloxy）-N-（3- cyano-l-（4-fluorophenyl）-lH-pyrazol-5-yl） acetamide （8）, was synthesized from the initial compound benzo[d]isothiazol-3（2H）-one （BIT） 1 and 4-fluoroaniline 3. The structure of the target compound 8 was determined by elemental analyses, IR and 1H NMR. The single crystals of intermediate compound 6 and the target compound 8 were obtained and determined by X-ray diffraction analysis. The preliminary biological activity was also evaluated and the results showed tile target compound exhibited a good anti-microbial activity.
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| 关 键 词： | 抗微生物活性 晶体结构 氟苯胺 乙酰胺 苯基 噻唑 合成 吡唑 |
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