| 含有环丙沙星高分子前药物的合成 |
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| 引用本文： | 连鸿丹,;叶艳秋,;董声雄.含有环丙沙星高分子前药物的合成[J].莆田高等专科学校学报,2008(5):54-57. |
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| 作者姓名： | 连鸿丹 ;叶艳秋 ;董声雄 |
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| 作者单位： | [1]湄洲湾职业技术学院化学工程系,福建莆田351254; [2]福州大学化学化工学院,福建福州350002 |
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| 基金项目： | 福建省科技厅重点项目（200610019） |
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| 摘 要： | 以抗菌药物-盐酸环丙沙星（CIPRO）代替传统的聚氨酯扩链剂，采用六亚甲基二异氰酸酯（HDI）、聚己内酯（PCL）为原料，通过典型的两步聚氨酯缩合反应，成功地将药物耦合到聚氨酯的骨架结构上，合成了环丙沙星-聚氨酯高分子前药物。研究了不同加料顺序对药物含量和平均分子量的影响。结果表明，合成的高分子前药物具有较高的药物含量、平均分子量和较窄的分散性。
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| 关 键 词： | 高分子前药物 环丙沙星 聚氨酯 |
Synthesis of Ciprofloxacin-Bonded Polymer Prodrug |
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| Institution: | LIAN Hong-dan, YE Yan-qiu, DONG Sheng-xiong ( 1. Chemistry ＆ Chemical Engineering Department, Meizhouwan Vocational ＆ Technical Colloge, Putian Fujian 351254, China; 2. College of Chemistry ＆ Chemical Engineering, Fuzhou University, Fuzhou Fujian 350002, China ) |
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| Abstract: | Antibiotic drug, ciprofloxacin hydrochloride which replaces the traditional chain extender, has been successfully incorporated as a monomer into the polyurethane backbone structure via a classical two-step polyurethane condensation reaction with 1,6-hexane diisocyanate （HDI） and polycaprolactone diol （PCL）. The sequential order of monomer feeding have been studied. The result shows the polyurethane-ciprofloxacin prodrug have high drug concentration, molecular weight and a relatively narrow polydispersity. |
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| Keywords: | polymer prodrug ciprofloxacin polyurethane |
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