Total synthesis of capreomycin |
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Authors: | S Nomoto T Teshima T Wakamiya T Shiba |
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Affiliation: | Department of Chemistry, Faculty of Science, Osaka University, Toyonaka, Osaka 560, Japan |
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Abstract: | Total syntheses have been achieved of capreomycin IA and IB according to our newly proposed structures. The β-lysine residue in the branch was introduced to the cyclic peptide moiety which was prepared by cyclization of the corresponding pentapeptide. Deprotection followed by conversion of β,β-diethoxyalanine residue to β-ureidodehydroalanine residue afforded the desired products, which were identical with natural capreomycins in all respects. |
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