Selection of SPE cartridge for automated solid-phase extraction of pesticides from water followed by liquid chromatography-tandem mass spectrometry |
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Authors: | Timothy B Jordan David S Nichols and Neil I Kerr |
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Institution: | (1) Analytical Services Tasmania, 18 St John’s Ave, New Town, Hobart, Tasmania, 7008, Australia |
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Abstract: | In environmental analyses there is an ever-increasing need to develop simple and sensitive multi-residue methods. In many
agricultural regions, there is particular concern of the potential for pesticides to enter rivers and other waterways. This
study reports on the development and validation of a multi-residue method of analysis for 30 pesticides in water samples using
solid-phase extraction (SPE) followed by LC-MS/MS. The electrospray and MS/MS parameters were optimised for each pesticide,
including capillary voltage, collision-induced dissociation voltage, and selection of a precursor ion and two product ions.
A variety of SPE sorbents were tested for sample pre-concentration, including numerous polymeric based phases. Bond Elut PPL
and Oasis HLB were the only phases capable of retaining the majority of the target analyte classes in a single method. An
off-line pre-concentration method using a Gilson Aspec system was optimised using the Bond Elut PPL cartridges, with a concentration
factor of 25 producing limits of quantitation in the order of 6–100 ng/L. Excellent linearity (r
2 > 0.9), precision (<20%) and recovery (>60%) was obtained for nearly all of the analytes, covering a wide variety of chemical
and physical properties. This is the first study to fully validate Bond Elut PPL cartridges for use in multi-residue pesticide
analysis. |
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Keywords: | SPE Bond Elut PPL Pesticide LC-MS/MS |
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