Highly Efficient Diastereoselective Synthesis of Tetrahydro-isoquinoline-3- carboxylate Ester Analogs from L-DOPA

Tetrahydroisoquinoline-3-carboxylate esters are an important motif of naturally occurring bioactive alkaloids and pharmacophores. They are generally regarded as neurotoxic compounds and are putatively involved in a variety of pathologic conditions of central nervous system, including alcoholism, phenylketonuria, and neurodegenerative disorders such as Parkinson's disease.