Analysis of small biopsy samples by neutron activation analysis

An accurate knowledge of the ratio Ca/P in bone biopsies is very useful in the diagnosis of osteoporosis. Similarly, measurements on muscle biopsies are important in understanding the disturbance of intracellular fluid and electrolyte (Na, Cl, K and P) balance in patients with metabolic myopathies (muscle diseases) and acid-base disturbances including renal failure. The ratio Ca/P in normal subjects was found to be 2.30. Similarly, the ratio K/P was found to be very nearly constant in normal subjects.