| p16基因在原发性肝癌中丢失的研究 |
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| 引用本文： | 杨定华,彭民浩,姜海行,李绍森,卢全书,卢榜裕.p16基因在原发性肝癌中丢失的研究[J].广西科学,1997,4(1):46-47. |
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| 作者姓名： | 杨定华 彭民浩 姜海行 李绍森 卢全书 卢榜裕 |
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| 作者单位： | 广西医科大学第一附院外一科 |
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| 摘 要： | 为了解抗癌基因Ｐ＾１６在原发性肝癌中的变异情况，采用判别技术研究３４例原发性肝癌及其癌组织。结果显示、１例原发性肝癌存在Ｐ＾１６Ｅｘｏｎｌ纯合子缺失，１５例原发怀肝癌存在Ｐ＾１６Ｅｘｏｎ２纯合子缺失，其余的１９例肝癌及所有的癌周组织无Ｐ＾１６基因纯合子失，研究结果表明Ｐ＾１６基因的缺失与原发性肝癌的发展发展密切相关，并提供了肝癌第９号染色体基因变的依据。
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| 关 键 词： | 原发性肝癌 P16基因 基因变异 肝癌 |
| 收稿时间： | 1997/1/17 0:00:00 |
| 修稿时间： | 1997/1/20 0:00:00 |
On the Loss of p16 Gene in Primary Hepatic Carcinoma |
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| Yang Dinghu,Peng Minhao,Jiang Haixing,Li Shaosheng,Lu Quanshu and Lu Bangyu.On the Loss of p16 Gene in Primary Hepatic Carcinoma[J].Guangxi Sciences,1997,4(1):46-47. |
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| Authors: | Yang Dinghu Peng Minhao Jiang Haixing Li Shaosheng Lu Quanshu and Lu Bangyu |
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| Institution: | Dept. of General Surgery, First Affiliated Hospital, Guangxi Medical Univ., 6 Binhu Road, Nanning, Guangxi, 530021,Dept. of General Surgery, First Affiliated Hospital, Guangxi Medical Univ., 6 Binhu Road, Nanning, Guangxi, 530021,Dept. of General Surgery, First Affiliated Hospital, Guangxi Medical Univ., 6 Binhu Road, Nanning, Guangxi, 530021,Dept. of General Surgery, First Affiliated Hospital, Guangxi Medical Univ., 6 Binhu Road, Nanning, Guangxi, 530021,Dept. of General Surgery, First Affiliated Hospital, Guangxi Medical Univ., 6 Binhu Road, Nanning, Guangxi, 530021 and Dept. of General Surgery, First Affiliated Hospital, Guangxi Medical Univ., 6 Binhu Road, Nanning, Guangxi, 530021 |
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| Abstract: | To determine the alteration of p 16 ,a novel antioncogene, in human primary hepatic carcinoma, 34 cases of primary hepatic carcinoma and tumor adjacent tissue were examined by Differential PCR.One case was showed as homozygous deletion of p 16 Exon1 and 15 cases as homozygus deletion of p 16 Exon2.It is indicated that p 16 gene deletion is associated with the occuring and development of primary hepatic carcinoma and provides an evidence of gene deletion of chromosome 9p in the human primary hepatic carcinoma. |
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| Keywords: | primary hepatic carcinoma p 16 gene loss |
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