Optical fiber SPR biosensor with sandwich assay for the detection of prostate specific antigen |
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| Authors: | Hyun Soo Jang Chang Duk Kang Sang Jun Sim |
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| Affiliation: | a School of Information and Communication Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea
b Department of Chemical Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea |
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| Abstract: | We present a new, sensitive, few mode fiber (FMF) surface plasmon resonance (SPR) biosensor with a sandwich assay for the detection of PSA. The side-polished FMF biosensor does not need a polarizer and a thin high-index overlayer. The optical sensitivity of the SPR sensor was determined as 2.5 × 10−6 RIU. In the SPR PSA sensor, the SPR signals were amplified by a factor of 6 in average over no secondary antibody, using the sandwich assay. The proposed FMF SPR biosensor has great potential for real-time analysis of immune reaction between biomolecules and the advantages of high-sensitivity and label-free detection. |
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| Keywords: | Optical fiber sensor Surface plasmon resonance (SPR) Biosensor Detection |
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