Synthesis and cytotoxic activity of 2,5-disubstituted pyrimido[5,4-c]quinoline derivatives |
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| Authors: | Fan Zhang Xin Zhai Li Juan Chen Jian Guo Qi Bo Cui Yu Cheng Gu Ping Gong |
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| Institution: | a Key Laboratory of New Drugs Design and Discovery of Liaoning Province, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China;b Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK |
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| Abstract: | A series of 2,5-disubstituted pyrimido5,4-c]quinoline derivatives were synthesized and their cytotoxic activity against H460, HT-29 and MDA-MB-231 cell lines was evaluated in vitro. It was found that most of the tested compounds especially compound 17, shown stronger activity to the selected three cell lines than ZM447439. |
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| Keywords: | Pyrimido[5 4-c]quinoline Synthesis Cytotoxic activity |
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