| 布洛芬晶体转晶与表征 |
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| 引用本文： | 周政,张奇.布洛芬晶体转晶与表征[J].光谱实验室,2006,23(2):212-215. |
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| 作者姓名： | 周政 张奇 |
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| 作者单位： | 北京理工大学化工与环境学院 北京市中关村南大街5号 100081 |
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| 摘 要： | 利用两种不同的有机溶剂乙醇和异丙醇以及三种添加剂葡萄糖、聚乙烯吡咯烷酮、十二烷基苯磺酸钠,通过非溶剂法转晶制得不同形态的布洛芬晶体,使用电子扫描显微镜(SEM),差热扫描量热仪(DSC),X射线粉晶衍射(XRPD)等方法对其进行了表征.利用表征结果研究了结晶体系极性和氢键对晶体生长的影响,发现溶剂和添加剂通过不同的作用方式影响晶体的生长规律.
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| 关 键 词： | 晶体表征 布洛芬 微晶体 转晶 |
| 文章编号： | 1004-8138(2006)02-0212-04 |
| 收稿时间： | 2005-10-31 |
| 修稿时间： | 2005-10-31 |
Characteristic and Evaluation of the Recrystallized Ibuprofen Crystal |
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| ZHOU Zheng,ZHANG Qi.Characteristic and Evaluation of the Recrystallized Ibuprofen Crystal[J].Chinese Journal of Spectroscopy Laboratory,2006,23(2):212-215. |
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| Authors: | ZHOU Zheng ZHANG Qi |
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| Institution: | School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijin g 100081, P. R. China |
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| Abstract: | The original ibuprofen crystal was recrystallized from two solvents by addition of three kinds of additives in the two kinds of drug solutions and pouring into the non-solution at the same temperature,and characterized by SEM,DSC and XRPD.The crystals have the same melting point and are homogenous.The effects of solvents and additives have some influences on the recrystallization. |
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| Keywords: | Crystal Morphology Ibuprofen Micro-Crystal Recrystallization |
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