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Synthesis of substituted 3-pyridinecarbonitriles with potential biological activity |
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| Authors: | C Oliver Kappe Thomas Kappe |
| Institution: | (1) Institut für Organische Chemie, Karl-Franzens-Universität Graz, A-8010 Graz, Österreich |
| Abstract: | Summary The synthesis of some 5-cyano-4-hydroxy-2-pyridone derivatives (3 a–c) by condensation of 3-aminocrotononitrile (1) with substituted diethylmalonates (2 a–c) is described. Reaction of3 a with phosphorus oxychloride yields 4,6-dichloro-3-pyridinecarbonitrile (7 a), which reacts with various nucleophiles to give substituted 3-pyridinecarbonitriles (8–10).See ref. 1] |
| Keywords: | 3-Pyridinecarbonitriles 4-Hydroxy-6-oxo-1 6-dihydro-3-pyridinecarbonitriles 4 6-Dichloro-3-pyridinecarbonitrile 3- Aminocrotononitrile |
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