Synthesis,characterization, and DNA-binding properties of copper(II), cobalt(II), and nickel(II) complexes with salicylaldehyde 2-phenylquinoline-4-carboylhydrazone |
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Authors: | Zhi-hong Xu Pin-xian Xi Feng-juan Chen Xiao-hui Liu Zheng-zhi Zeng |
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Institution: | (1) College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, P.R. China |
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Abstract: | Salicylaldehyde 2-phenylquinoline-4-carboylhydrazone (H2L), and its novel copper(II), cobalt(II), and nickel(II) complexes MHL · Cl · nH2O M=Cu n = 3 (1), M=Co n = 2 (2), M=Ni n = 3.5 (3)] have been synthesized and characterized by elemental analysis, molar conductivity, spectroscopic, and thermal analysis.
The interaction of these complexes with calf thymus DNA was investigated by UV absorption spectroscopy, fluorescence spectroscopy,
cyclic voltammetry, and viscosity measurements. The results suggest that these complexes bind to DNA via an intercalation
binding mode and their affinity to DNA follows the order of 3 > 1> 2.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. |
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