Planar triazinium cations from VO(2+)-assisted ring cyclizations: a remarkably efficient thiazole species for nuclear staining, PDT and anaerobic photocleavage of DNA |
| |
Authors: | Prasad Puja Khan Imran Sasmal Pijus K Koley Debasis Kondaiah Paturu Chakravarty Akhil R |
| |
Institution: | Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India. |
| |
Abstract: | Planar triazinium cationic species, from VO(2+)-assisted cyclization of 1-(2-thiazolylazo)-2-naphthol, shows efficient DNA intercalative binding, visible light-induced anaerobic plasmid DNA photocleavage activity and photocytotoxicity in HeLa and MCF-7 cancer cells by an apoptotic pathway with selective localization of the compound in the nucleus as evidenced from the nuclear staining and confocal imaging. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|