Drug resistance modulation in Staphylococcus aureus, a new biological activity for mesoionic hydrochloride compounds |
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Authors: | de Oliveira Cledualdo Soares Falcão-Silva Vivyanne dos Santos Siqueira José Pinto Harding David Peter Lira Bruno Freitas Lorenzo Jorge Gonçalo Fernandes Barbosa-Filho José Maria de Athayde-Filho Petrônio Filgueiras |
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Affiliation: | Department of Chemistry, Federal University of Paraíba, 58059 Jo?o Pessoa, PB, Brazil. |
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Abstract: | Two salts of the mesoionic compounds 1,4-diphenyl-5-(5-nitro-2-furanyl)-1,3,4-thiadiazolium-2-thiol chloride (MC-1) and 4-phenyl-5-(5-nitro-2-furanyl)-1,3,4-thiadiazolium-2-phenylamine chloride (MC-2) were synthesized utilizing 1,4-diphenyl-thiosemicarbazide and 5-nitro-2-furoyl chloride as starting materials. Their structures were characterized by IR, 1H-NMR, 13C-NMR and elemental analysis. These compounds were analyzed for their influence on the effectiveness of norfloxacin, tetracycline, and erythromycin (standard antibiotics) against resistant strains of Staphylococcus aureus. MC-1 and MC-2, at sub-inhibitory concentrations of 16 μg/mL, favourably modulated the antibiotic activity of tetracycline by 16- and 32-fold, respectively (MIC), and that of erythromycin by 4-fold. |
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