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| Nanoscale viscoelastic properties and adhesion of polydimethylsiloxane for tissue engineering简 | |
| 引用本文： | J.Chen,K.E·Wright,M.A.Birch. Nanoscale viscoelastic properties and adhesion of polydimethylsiloxane for tissue engineering简[J]. Acta Mechanica Sinica, 2014, 30(1): 2-6. DOI: 10.1007/s10409-014-0022-0 |
| 作者姓名： | J.Chen K.E·Wright M.A.Birch |
| 作者单位： | [1]School of Mechanical ＆ Systems Engineering,Newcastle University, Newcastle Upon Tyne, UK [2]Arthritis Research UK （ARUK） Tissue Engineering Centre,Institute of Cellular Medicine,Newcastle University, UK [3]St James＇ University Hospital,University of Leeds, UK |
| 基金项目： | funded by EPSRC–Newcastle University Sandpit Workshop Award |
| 摘 要： | It has shown that altering crosslink density of biopolymers will regulate the morphology of Mesenchymal Stem Cells （MSCs） and the subsequent MSCs differentia- tion. These observations have been found in a wide range of biopolymers. However, a recent work published in Nature Materials has revealed that MSCs morphology and differen- tiation was unaffected by crosslink density of polydimethyl- siloxane （PDMS）, which remains elusive. To understand such unusual behaviour, we use nanoindentation tests and modelling to characterize viscoelastic properties and sur- face adhesion of PDMS with different base：crosslink ratio varied from 50：1 （50D） to 10：1 （10D）. It has shown that lower crosslink density leads to lower elastic moduli. De- spite lower nanoindentation elastic moduli, PDMS with lowest crosslink density has higher local surface adhesion which would affect cell-biomaterials interactions. This work suggests that surface adhesion is likely another important physical cue to regulate cell-biomaterials interactions. |
| 关 键 词： | 聚二甲基硅氧烷 纳米压痕 粘弹性能 组织工程 骨髓间充质干细胞 交联密度 粘连 PDMS |
Nanoscale viscoelastic properties and adhesion of polydimethylsiloxane for tissue engineering |
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| J. Chen,K. E. Wright,M. A. Birch. Nanoscale viscoelastic properties and adhesion of polydimethylsiloxane for tissue engineering[J]. Acta Mechanica Sinica, 2014, 30(1): 2-6. DOI: 10.1007/s10409-014-0022-0 | |
| Authors: | J. Chen K. E. Wright M. A. Birch |
| Affiliation: | 1. School of Mechanical & Systems Engineering, Newcastle University, Newcastle Upon Tyne, UK 2. Arthritis Research UK (ARUK) Tissue Engineering Centre, Institute of Cellular Medicine, Newcastle University, Newcastle, UK 3. St James’ University Hospital, University of Leeds, Leeds, UK |
| Abstract: | It has shown that altering crosslink density of biopolymers will regulate the morphology of Mesenchymal Stem Cells (MSCs) and the subsequent MSCs differentiation. These observations have been found in a wide range of biopolymers. However, a recent work published in Nature Materials has revealed that MSCs morphology and differentiation was unaffected by crosslink density of polydimethylsiloxane (PDMS), which remains elusive. To understand such unusual behaviour, we use nanoindentation tests and modelling to characterize viscoelastic properties and surface adhesion of PDMS with different base:crosslink ratio varied from 50:1 (50D) to 10:1 (10D). It has shown that lower crosslink density leads to lower elastic moduli. Despite lower nanoindentation elastic moduli, PDMS with lowest crosslink density has higher local surface adhesion which would affect cell-biomaterials interactions. This work suggests that surface adhesion is likely another important physical cue to regulate cell-biomaterials interactions. |
| Keywords: | Bioploymer Nanoindentation Viscoelasticity Surface adhesion |
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