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Polypeptide dendrimers: Self-assembly and drug delivery |
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| Authors: | XU XiangHui LI CaiXia LI HaiPing LIU Rong JIANG Chao WU Yao HE Bin & GU ZhongWei National Engineering Research Center for Biomaterials Sichuan University Chengdu China |
| Institution: | XU XiangHui,LI CaiXia,LI HaiPing,LIU Rong,JIANG Chao,WU Yao,HE Bin* & GU ZhongWei* National Engineering Research Center for Biomaterials,Sichuan University,Chengdu 610064,China |
| Abstract: | Amphiphilic dendritic poly(glutamic acid)-b-polyphenylalanine copolymers were synthesized using generation 3 dendritic poly(glutamic acid) as the macroinitiator in the ring-opening polymerization of NCA-Phe.The block copolymers self-assembled micelles with polyphenylalanine segments as core and dendritic poly(glutamic acid) segments as shell.The biocompatibility of the micelles was studied.The release of the anticancer drug doxorubicin from the micelles was investigated in vitro.The results showed that the ... |
| Keywords: | self-assembly dendritic polypeptide block copolymer drug delivery |
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