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Organocatalytic asymmetric allylic alkylation of sulfonylimidates with Morita-Baylis-Hillman carbonates |
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| Authors: | PENG Jing CUI HaiLei & CHEN YingChun Key Laboratory of Drug-Targeting Drug Delivery System Ministry of Education |
| Affiliation: | PENG Jing,CUI HaiLei & CHEN YingChun Key Laboratory of Drug-Targeting and Drug Delivery System,Ministry of Education,Department of Medicinal Chemistry,West China School of Pharmacy,Sichuan University,Chengdu 610041,China |
| Abstract: | The asymmetric allylic alkylation reaction of sulfonylimidates with various Morita-Baylis-Hillman (MBH) carbonates was accomplished by the catalysis of commercially available cinchona alkaloids catalyst (DHQD)2AQN.The corresponding allylic alkylation products were obtained in good yields with high stereoselectivities (up to 99% ee,89:11 dr). |
| Keywords: | organocatalysis asymmetric allylic alkylation sulfonylimidates Morita-Baylis-Hillman carbonates cinchona alkaloids |
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