| 流感病毒糖蛋白糖链的作用和功能研究 |
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| 引用本文： | 孙士生,王秦哲,李铮.流感病毒糖蛋白糖链的作用和功能研究[J].中国科学:化学,2011(3):424-432. |
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| 作者姓名： | 孙士生 王秦哲 李铮 |
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| 作者单位： | 西北大学生命科学学院功能糖组学实验室; |
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| 基金项目： | 国家高技术研究发展计划项目(2007AA02Z413); 科技部国际科技合作计划项目(2009DFA32730)资助 |
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| 摘 要： | 流感病毒是近几年的研究热点之一.糖链在流感病毒生活周期中发挥重要作用,例如宿主细胞表面的唾液酸化糖链是病毒侵染细胞时的特异性受体,宿主决定的病毒糖蛋白糖链结构影响病毒的宿主范围和毒力.本文从糖组学角度综述糖链在甲型流感病毒生活周期中的重要作用,着重阐述病毒血凝素糖基化的影响因素及其对病毒宿主范围、毒力的影响和在病毒演化...
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| 关 键 词： | 流感病毒 糖链 血凝素 宿主 毒力 |
The effect and function of glycosylation for influenza virus |
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| SUN ShiSheng,WANG QinZhe ＆ LI Zheng.The effect and function of glycosylation for influenza virus[J].Scientia Sinica Chimica,2011(3):424-432. |
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| Authors: | SUN ShiSheng WANG QinZhe ＆ LI Zheng |
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| Institution: | Laboratory for Functional Glycomics, College of Life Sciences, Northwest University, Xi’an 710069, China |
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| Abstract: | Influenza is an acute viral disease of the respiratory tract that affects millions of people each year. Glycan plays an important role in the life cycle of influenza virus. The study of N-linked glycosylation and related virus biology has become an area of intense interest in recent years due to its ability to impart various advantages to virus survival and virulence as well as host specificity. For example, the sialylated glycans on the host cell surface were the specific receptor for influenza virus and v... |
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| Keywords: | influenza virus glycosylation hemagglutinin host virulence |
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