Facile synthesis of N-6 adenosine modified analogue toward S-adenosyl methionine derived probe for protein arginine methyltransferases |
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Authors: | Wei Hong James Dowden |
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Institution: | a School of Chemistry and Chemical Engineering, Beifang University of Nationalities, Yinchuan 750021, China;b School of Chemistry, University of Nottingham, Nottingham NG7 2RD, UK |
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Abstract: | Chemically modified cellular co-factors that provide function, such as immobilization or incorporation of fluorescent dyes, are valuable probes of biological activity. A convenient route to obtain S-adenosyl methionine (AdoMet) analogues modified at N-6 adenosine to feature a linker terminating in azide functionality is described herein. Subsequent decoration of such AdoMet analogues with guanidinium terminated linkers leads to novel potential bisubstrate inhibitors for protein arginine methyltransferases, PRMTs. |
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Keywords: | Protein arginine methyltransferases S-Adenosyl methionine Nucleosides |
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