Catalytic enantioselective conjugate addition of aromatic amines to fumarate derivatives: asymmetric synthesis of aspartic acid derivatives |
| |
Authors: | Seung Hee Kang Young Ku Kang Dae Young Kim |
| |
Institution: | Department of Chemistry, Soonchunhyang University, Asan, Chungnam 336-745, Republic of Korea |
| |
Abstract: | The catalytic enantioselective conjugate addition of aromatic amines to fumarate derivatives promoted by chiral palladium complexes is described. Treatment of aniline derivatives with fumaryl pyrrolidinone as Michael acceptor under mild reaction conditions afforded the corresponding chiral aspartic acid derivatives with excellent enantiomeric excesses (83–96% ee). |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |