Latrunculin,a new 2-thiazolidinone macrolide from the marine sponge |
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Authors: | Y Kashman A Groweiss U Shmueli |
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Institution: | Department of Chemistry, Tel-Aviv University, Tel Aviv, Israel |
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Abstract: | Three new toxins were isolated from the Red Sea sponge A full structure determination of these toxins, by spectroscopic methods, was aided by an X-ray diffraction analysis of a crystalline derivative (b) of latrunculin-A. The Latrunculins exhibit a new class of 14 and 16 membered macrolides to which the rare 2-thiazolidinone moiety is attached. A biogenesis of these biologically active compounds is put forward. |
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