A novel route to dipeptide and its derivative by means of the palladium catalyzed facile cleavage of 1-(1-methoxycarbonyl)alkyl-3-substituted-4-arylazetidin-2-ones期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

A novel route to dipeptide and its derivative by means of the palladium catalyzed facile cleavage of 1-(1-methoxycarbonyl)alkyl-3-substituted-4-arylazetidin-2-ones

Authors:	Iwao Ojima Shigemi Suga Rumiko Abe

Affiliation:	Sagami Chemical Research Center, Nishi-Ohnuma 4-4-1, Sagamihara, Kanagawa 229 Japan

Abstract:	1-(1-Methoxycarbonyl)alkyl-3-substituted-4-arylazetidin-2-ones were found to be cleaved exclusively at the NC⁴ bond by the hydrogenolysis on palladium catalyst to give the corresponding dipeptide and its derivative in excellent yields.

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