Asymmetric grignard cross-coupling by means of polymer-supported optically active β-dimethylaminoalkylphosphine-nickel catalysts |
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| Authors: | Tamio Hayashi Nobuo Nagashima Makoto Kumada |
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| Affiliation: | Department of Synthetic Chemistry, Kyoto University, Kyoto 606, Japan |
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| Abstract: | New polymer ligands containing β-dimethylaminoalkylphosphines were prepared using chloromethylated polystyrene, and the ligands were used for nickel-catalyzed asymmetric cross-coupling of sec-alkyl Grignard reagents with vinyl bromide to yield coupling products of ～50% ee. |
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