Tandem conjugate addition-α-alkylation of unsaturated amides. Synthetic methodology. |
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| Authors: | GB Mpango KK Mahalanabis Z Mahdavi-Damghani V Snieckus |
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| Institution: | The Guelph-Waterloo Centre for Graduate Work in Chemistry, Waterloo Campus Department of Chemistry, University of Waterloo, Waterloo, Canada N2L 3G1 |
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| Abstract: | 1,4-Addition of RLi, RMgX, and (RS) 2CHLi reagents to unsaturated amides 2a-c followed by α-alkylation is shown to constitute a general and efficient synthetic procedure for the formation of two CC bonds in a single step. |
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