Facile oxidative conversion of hydrazides of carboxylic acids to corresponding acids,esters and amides using copper compounds |
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| Authors: | Jiro Tsuji Toshiharu Nagashima Nguyen Thi Qui Hiroshi Takayanagi |
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| Institution: | Department of Chemical Engineering, Tokyo Institute of Technology, Meguro, Tokyo 152, Japan |
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| Abstract: | Oxidative conversion of hydrazides of carboxylic acids to acids, esters and amides using Cu salts was studied. Acids were obtained in high yields by using a catalytic amount of Cu(OAc)2 at room temperature by bubbling oxygen. Hydrazides were converted to esters by the treatment with Cu(OR)Cl or Cu(OR)2 formed in situ from CuCl2 and sodium alkoxide. Amides were obtained in high yields by the oxidation of hydrazides with CuCl2 in the presence of amines. |
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