First asymmetric total synthesis of (+)-steganacin determination of absolute stereochemistry |
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| Authors: | Kiyoshi Tomioka Tsuneo Ishiguro Kenji Koga |
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| Institution: | Faculty of Pharmaceutical Sciences, University of Tokyo Hongo, Bunkyo-ku, Tokyo 113, Japan |
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| Abstract: | (+)-Steganacin was synthesized in a new and highly specific asymmetric pathway based on the novel application of chiral γ-lactone as a chiral synthon. By this synthesis the absolute stereochemistry of natural (?)-steganacin could be determined in unequivocal way. |
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