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| Parallel Synthesis of Tetraaryl-4,5-dihydro-1,2,4-triazoles via 1,3-Dipolar Cycloaddition on Soluble Polymer Support | |
| 引用本文： | SHOU,Wang-Ge WANG,Yan-Guang. Parallel Synthesis of Tetraaryl-4,5-dihydro-1,2,4-triazoles via 1,3-Dipolar Cycloaddition on Soluble Polymer Support[J]. 有机化学, 2004, 24(Z1): 340 |
| 作者姓名： | SHOU Wang-Ge WANG Yan-Guang |
| 作者单位： | SHOU,Wang-Ge（Department of Chemistry, Zhejiang University, Hangzhou 310027） WANG,Yan-Guang（Department of Chemistry, Zhejiang University, Hangzhou 310027） |
| 摘 要： | The polymer-supported liquid-phase synthesis of small organic molecules has been a subject of intense research activity. 1,2,4-Triazoles are well known for their antifungal[1] and antibacterial[2] activities. This moiety was also found in potent agonist or antagonist receptor lingands. The synthesis of substituted 1,2,4-triazoles via 1,3-dipolar cycloaddition of imines with nitrilimines is well documented.[3] Herein, we would like to report the first liquid-phase synthesis of 1,3,4,5-tetraaryl-4,5-dihydro-1,2,4-triazoles through a 1,3-dipolar cycloaddition of imines with nitrilimines on PEG support. |
Parallel Synthesis of Tetraaryl-4,5-dihydro-1,2,4-triazoles via 1,3-Dipolar Cycloaddition on Soluble Polymer Support |
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| SHOU,Wang-Ge,WANG,Yan-Guang. Parallel Synthesis of Tetraaryl-4,5-dihydro-1,2,4-triazoles via 1,3-Dipolar Cycloaddition on Soluble Polymer Support[J]. Chinese Journal of Organic Chemistry, 2004, 24(Z1): 340 | |
| Authors: | SHOU Wang-Ge WANG Yan-Guang |
| Abstract: | The polymer-supported liquid-phase synthesis of small organic molecules has been a subject of intense research activity. 1,2,4-Triazoles are well known for their antifungal[1] and antibacterial[2] activities. This moiety was also found in potent agonist or antagonist receptor lingands. The synthesis of substituted 1,2,4-triazoles via 1,3-dipolar cycloaddition of imines with nitrilimines is well documented.[3] Herein, we would like to report the first liquid-phase synthesis of 1,3,4,5-tetraaryl-4,5-dihydro-1,2,4-triazoles through a 1,3-dipolar cycloaddition of imines with nitrilimines on PEG support. |
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