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Advances in magnetofection—magnetically guided nucleic acid delivery

Institution:	1. S.C. Cardiochirurgia, Department of Cardiology and Cardiovascular Surgery, Niguarda Ca'' Granda Hospital, Milan, Italy;2. S.C. Cardiologia IV, Department of Cardiology and Cardiovascular Surgery, Niguarda Ca'' Granda Hospital, Milan, Italy;3. ANMCO Research Center, Florence, Italy;4. Department of Cardiovascular Research, IRCCS Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy;5. Department of Cardiac, Vascular and Thoracic Sciences, University of Padua, Padua, Italy;6. Cardiovascular Pathology, Department of Cardiological, Thoracic and Vascular Sciences, University of Padua, Padua, Italy;7. Cardiothoracic Surgery, ICLAS–Istituto Clinico Ligure Alta Specialità, Rapallo, Italy;8. Heart Care Foundation, Florence, Italy

Abstract:	Magnetofection is nucleic acid delivery to cells supported and site-specifically guided by the attractive forces of magnetic fields acting on nucleic acid shuttles (vectors) which are associated with magnetic nanoparticles. Recent progress with the method confirms its general applicability with small and large nucleic acids and viruses. The method's therapeutic application as well as mechanistic studies will be discussed.

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