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Multifunctional magnetite and silica–magnetite nanoparticles: Synthesis,surface activation and applications in life sciences
Institution:1. School of Science, University of Greenwich, Chatham, Kent ME6 4BT, UK;2. Instituto di Scienze Chimiche, Universita degli Studi di Urbino, Piazza Rinascimento 6, 61029 Urbino, Italy;3. Department of Chemistry, Bar llan University, Ramat Gan 52900, Israel;1. Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada;2. Biomedical Engineering Department, The Cleveland Clinic Foundation, Cleveland, Ohio, USA;1. Analytical Biosensors Group (GBA), Analytical Chemistry Department, Faculty of Sciences, University of Zaragoza, C/Pedro Cerbuna 12, 50009 Zaragoza, Spain;2. Institute of Nanoscience of Aragón (INA), University of Zaragoza, Zaragoza, Spain;1. Sonochemical Research Center, Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, 91779, Mashhad, Iran;2. Environmental Chemistry Research Center, Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, 91779, Mashhad, Iran;3. Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, 91779, Mashhad, Iran;1. Université Grenoble Alpes, INAC–SPrAM, F-38000 Grenoble, France;2. Centre National de la Recherche Scientifique (CNRS), SPrAM, F-38000 Grenoble, France;3. Centre d’Etudes Atomiques (CEA), INAC–SPrAM, F-38000 Grenoble, France;1. Laboratory of Materials, Molecules and Applications, IPEST, University of Carthage, Sidi Bou Said Road, B.P. 51 2070, La Marsa, Tunisia;2. Faculté des Sciences de Bizerte, Université de Carthage, Bizerte, Tunisia;3. Université Paris Est, ICMPE (UMR 7182), CNRS, UPEC, 2-8 rue Henri Dunant, 94320 Thiais, France;1. Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Jl. Semarang 5, Malang, 65145, Indonesia;2. Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Jl. Semarang 5, Malang, 65145, Indonesia;1. College of Materials Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, China;2. College of Petroleum Engineering, Northeast Petroleum University, Daqing 163318, China
Abstract:A method for the introduction of amine groups onto the surface of magnetite and silica-coated magnetite nanoparticles has been established based on the condensation of aminopropyltriethoxysilane. Amine-modified particles were grafted with an oligonucleotide and used in the capture of a complimentary sequence. The particles’ efficiency at capture was observed to correlate directly with amine group surface density.
Keywords:
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