Superparamagnetic nanoparticles for biomedical applications: Possibilities and limitations of a new drug delivery system |
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| Affiliation: | 1. Department of Chemistry Polymer Research Institute, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea;2. Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang 790-784, Republic of Korea;3. School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea;4. Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 136-791 and KU-KIST School, Korea University, Seoul 02841, Republic of Korea;5. Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu 700-421, Republic of Korea;6. Bioengineering Department, University of Washington, Seattle, Washington 98195, USA |
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| Abstract: | Nanoparticles can be used in biomedical applications, where they facilitate laboratory diagnostics, or in medical drug targeting. They are used for in vivo applications such as contrast agent for magnetic resonance imaging (MRI), for tumor therapy or cardiovascular disease. Very promising nanoparticles for these applications are superparamagnetic nanoparticles based on a core consisting of iron oxides (SPION) that can be targeted through external magnets. SPION are coated with biocompatible materials and can be functionalized with drugs, proteins or plasmids. In this review, the characteristics and applications of SPION in the biomedical sector are introduced and discussed. |
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