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Magic ferritin: A novel chemotherapeutic encapsulation bullet
Affiliation:1. CAU & ACC Joint-Laboratory of Space Food, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing Key Laboratory of Functional Food from Plant Resources, Beijing 100083, China;2. School of Chinese Medicine, Chinese University of Hong Kong, Hong Kong, China;3. Shenzhen Development Office, Chinese University of Hong Kong, Shenzhen, China.;1. Institute of Molecular Biology and Pathology, CNR – National Research Council of Italy, 00185 Rome, Italy;2. Department of Biochemical Sciences “A. Rossi-Fanelli”, “Sapienza” University, 00185 Rome, Italy;3. Institute of Biochemistry and Clinical Biochemistry, Catholic University of Sacred Heart, 00168 Rome, Italy;4. Department of Anatomical, Histological, Forensic & Orthopedic Sciences, Section of Histology & Medical Embryology, “Sapienza” University, 00161 Rome, Italy;5. Oncogenomics and Epigenetics, Regina Elena National Cancer Institute, 00144 Rome, Italy;6. BSP Pharmaceuticals, 04013 Latina, Italy;7. Department of Medicine, University of Verona, 37134 Verona, Italy
Abstract:The dissociation of apoferritin into subunits at pH 2 followed by its reformation at pH 7.4 in the presence of doxorubicin–HCl gives rise to a solution containing five doxorubicin–HCl molecules trapped within the apoferritin. This is the first report showing that ferritin can encapsulate an anti-cancer drug into its cavity.
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