Multifunctional nanoparticle platforms for in vivo MRI enhancement and photodynamic therapy of a rat brain cancer |
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| Affiliation: | 1. Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India;2. Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835215, India;3. Pharmaceutics Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India;4. Department of Life Sciences, Presidency University, Kolkata 700073, West Bengal, India;5. Department of Biochemistry, Kakatiya Medical College, Warangal 506007, Telangana, India;6. Applied Biology, CSIR-Indian Institute of Technology, Uppal Road, Hyderabad 500007, India;7. Department of Biomedical Sciences, School of Bio Sciences and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu 632014, India;8. Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, UP 201310, India;9. Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, P.O. Box 15551, Abu Dhabi, United Arab Emirates;10. Molecular Neuroscience and Functional Genomics Laboratory, Delhi Technological University (Formerly Delhi College of Engineering), Delhi, India;11. Department of Biotechnology Engineering and Food Technology, Chandigarh University, Mohali 140413, India;12. Department of Biotechnology, School of Applied & Life Sciences (SALS), Uttaranchal University, Dehradun 248007, India |
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| Abstract: | A paradigm for brain cancer detection, treatment, and monitoring is established. Multifunctional biomedical nanoparticles (30–60 nm) containing photosensitizer externally deliver reactive oxygen species (ROS) to cancer cells while simultaneously enhancing magnetic resonance imaging (MRI) contrast providing real-time tumor kill measurement. Plasma residence time control and specific cell targeting are achieved. A 5 min treatment in rats halted and even reversed in vivo tumor growth after 3–4 days post-treatment. |
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