Theoretical analysis of a transdermal ferromagnetic implant for retention of magnetic drug carrier particles |
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| Institution: | 1. Department of Chemical Engineering, University of South Carolina, Columbia, SC 29208, USA;2. Departments of Neurology and Surgery (Neurosurgery), University of Chicago, Pritzker School of Medicine, Chicago, IL 60637, USA;3. Chemical Engineering Division, Argonne National Laboratory, Argonne, IL 60439, USA;1. Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada;2. Biomedical Engineering Department, The Cleveland Clinic Foundation, Cleveland, Ohio, USA;1. Sobolev Institute of Geology and Mineralogy, Siberian Branch of Russian Academy of Sciences, 3 Academician Koptyug Avenue, 630090 Novosibirsk, Russia;2. Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of Russian Academy of Sciences, 18 Academician Kutateladze Street, 630128 Novosibirsk, Russia;3. Novosibirsk State University, 2 Pirogov Street, 630090 Novosibirsk, Russia;1. College of Physics and Technology, Shenzhen University, Shenzhen 518060, Guangdong, PR China;2. Department of Electronic Engineering and Materials Science and Technology Research Center, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong Special Administrative Region;1. State Key Laboratory of Ultra-precision Machining Technology, Department of Industrial and Systems Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, PR China;2. Department of Physics and Astronomy, The University of Western Ontario, 1151 Richmond Street, London, Ontario, N6A 3K7, Canada;3. A & P Instruments Co., Ltd, Room 68, 1/F Sino Industrial Plaza, 9 Kai Cheung Road, Kowloon Bay, Hong Kong SAR, PR China |
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| Abstract: | The use of a ferromagnetic wire implant placed near an artery to assist the collection of magnetic drug carrier particles (MDCPs) using an external magnet is theoretically studied. Three magnetic drug targeting (MDT) systems are evaluated in terms of their MDCP collection efficiency (CE): a permanent magnet and wire is better than a permanent magnet alone, which is better than a homogeneous magnetic field and wire. |
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