Intraarticular application of superparamagnetic nanoparticles and their uptake by synovial membrane—an experimental study in sheep |
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| Institution: | 1. Musculoskeletal Research Unit, Equine Hospital, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland;2. Department of Chemistry and Applied BioSciences, Swiss Federal Institute of Technology Zurich (ETH Zurich), Winterthurerstrasse 190, 8057 Zurich, Switzerland;3. Laboratory of Powder Technology, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland;4. MatSearch, Chemin Jean Pavillard 14, 1009 Pully, Switzerland;1. Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada;2. Biomedical Engineering Department, The Cleveland Clinic Foundation, Cleveland, Ohio, USA;1. National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China;2. Jiangsu Province Key Laboratory of Stem Cell Research,Medical College,Soochow University, Suzhou 215123,China;3. College of Textile & Clothing, Qingdao University, Qingdao 266071, China;1. National Engineering Laboratory for Modern Silk, Soochow University, Suzhou 215123, China;2. Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA;3. Department of Chemistry, Western Washington University, Bellingham, WA 98225, USA;1. College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009, Jiangsu, China;2. State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing University of Technology, Nanjing 210009, Jiangsu, China;1. Dept. of Engineering Materials and Mechanical Design, Faculty of Engineering, South Valley University, Qena 83523, Egypt;2. Dept. of Manufacturing Engineering, College of Engineering and Computer Science, University of Texas Pan-American, 1201 West University Dr., Edinburg, TX 78541-2999, USA;3. Dept. of Mechanical Engineering, College of Engineering, King Saud University, P.O. Box 800, Riyadh 11421, Saudi Arabia;4. Dept. of Mechanical Engineering, Faculty of Energy Engineering, Aswan University, Aswan, Egypt |
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| Abstract: | A superparamagnetic iron oxide nanoparticle, coated with polyvinyl alcohol, (PVA-SPION) and its fluorescently functionalized analogue (amino-PVA-Cy3.5-SPION) were compared in vivo as proof of principle for future use in magnetic drug targeting in inflammatory joint diseases. They were injected either intraarticularly or periarticularly and their uptake by cells of the synovial membrane was evaluated. Uptake was completed in 48 h and was enforced by an extracorporally applied magnet. |
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