Novel core–shell magnetic nanogels synthesized in an emulsion-free aqueous system under UV irradiation for targeted radiopharmaceutical applications |
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| Institution: | 1. Dept. of Molecular Engineering of Materials, Center of Applied Physics and Advanced Technology, National Autonomous University of Mexico (CFATA-UNAM), Boulevard Juriquilla 3001, Santiago de Querétaro, Querétaro 76230, Mexico;2. University of the Valley of Mexico (UVM), Boulevard Villas del Mesón 1000, Juriquilla, Santiago de Querétaro, Querétaro 76320, Mexico;1. Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX;2. Department of Surgery, University of Texas Medical Branch, Galveston, TX;3. Shriners Hospitals for Children, Galveston, TX;4. Sulpizio Cardiovascular Center, University of California, San Diego, CA;5. University of Arkansas for Medical Sciences, Little Rock, AR |
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| Abstract: | Novel core–shell poly(acrylamide) magnetic nanogels with controllable particle size produced via a photochemical method in an emulsion-free aqueous system at room temperature have been developed for the first time. After Hoffmann elimination of carbonyl, nanogels with amino groups, or poly(acrylamide-vinyl amine) magnetic nanogels, were also obtained. Particle size, size distributions and zeta potential of the magnetic nanogels before and after Hoffmann elimination were measured by photo-correlation spectroscopy (PCS). The structure and morphology of the magnetic nanogels were characterized by Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM) and atomic force microscopy (AFM). The higher dispersibility and stability of the magnetic nanogels suggest promising potential applications in targeted radiopharmaceuticals carriers for cancer therapy, and in biological and medical studies as well. |
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